Scientist, Antibody Engineering

Overview:

We are seeking a Scientist to join the Protein Sciences team to design and validate antibody molecules for the targeted delivery of oligonucleotides. The candidate will work across teams to validate receptors, assist with antibody discovery campaigns, and advance lead molecules for conjugation. The candidate will bring expertise in antibody engineering and receptor validation.

This position is onsite and will be primarily located in Cambridge, MA.

Responsibilities:

• Design antibodies and antibody fragments across multiple formats (bispecifics, Fc fusions, Fabs, scFvs).
• Research tool antibody molecules for target validation and assist with antibody discovery campaigns for selected targets.
• Model antibody structures using relevant software like Pymol and ChimeraX.
• Characterize protein quality and stability using methods like SDS-PAGE, melting point, size-exclusion chromatography, ion exchange, UV-Vis, DLS, and ELISA.
• Work with CROs to produce antibodies and troubleshoot expression issues.
• Develop and perform binding assays using BLI (Octet) or SPR (Biacore) for epitope binning and determination of kinetic binding parameters.
• Meet quality, quantity, and timelines in all assigned projects.
• Proper electronic notebook record keeping.
• Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities.

Qualifications:

• PhD degree with 1-2 years of relevant experience with a focus on antibody design and engineering.
• Deep understanding of antibody design, protein structure and protein purification across multiple formats including bispecifics, Fc fusions, Fabs, and scFvs.
• Strong technical background in antibody characterization includes binding kinetics and therapeutic applications for target mediated delivery.
• Experience with recombinant protein analysis for monoclonal antibodies (SDS-PAGE, size exclusion chromatography, reverse phase chromatography, hydrophobic interaction chromatography, ion exchange chromatography, and UV-VIS spectroscopy).
• Passionate about driving his or her projects from the bench to independently contribute to research directions and solve challenging issues.
• Detail oriented, self-motivated, and comfortable working with highly technical projects.
• Ability to work on multiple projects simultaneously and deliver conclusive results.
• Highly adaptable and responsive to new priorities in a fast-paced environment.
• Effective written and oral communication skills.
• Experience preparing and presenting using PowerPoint software.
• Team oriented with strong work ethic

#LI-KB1 #LI-Hybrid

U.S. Pay Range

$110,400.00 - $165,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.