Principal Scientist, Antibody Cell Line Development

Overview:

We are seeking a Principal Scientist to join the Protein Sciences team to drive cell line and upstream process development for the production of monoclonal antibodies and antibody-oligo conjugates. The candidate will work across functions to advance molecules from discovery through to clinical readiness and will oversee all activities at selected CDMOs. The candidate will bring deep expertise in cell line development and act as the liaison between Research and CMC to ensure smooth transition from discovery to manufacturing.

This position is onsite and will be located at our Kendall Square offices in Cambridge, MA.

Responsibilities:

• Lead the development, selection, and characterization of stable, high-titer cell lines for the production of monoclonal antibodies and antibody-oligo conjugates.
• Evaluate, select, and manage CDMOs to execute regulatory-compliant cell line development activities including clonality documentation and cell bank generation.
• Supervise all cell line development processes including construct design, generation of stable pools, clone screening, characterization, and cell line stability.
• Analyze protocols, development reports, and other data packages generated by CDMOs.
• Ensure activities completed at CDMOs align with project goals, timelines, and quality standards.
• Support regulatory filings by authoring and reviewing relevant sections related to cell line development.
• Work cross-functionally with internal teams including research, CMC, regulatory, and clinical to ensure seamless transfer of knowledge.
• Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities.

Qualifications:

• Ph.D. in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences, Biology, or related field with 6-10 years of relevant experience.
• Deep expertise in cell line development for production of therapeutic proteins including monoclonal antibodies, antibody-drug conjugates, or antibody-oligo conjugates.
• Strong technical background in all aspects of cell line development including molecular biology, vector design, single cell cloning technologies, cell line characterization, and industry-leading antibody production platforms.
• Additional expertise in antibody design and protein engineering is a plus.
• Proven track record of managing CDMOs and delivering on biologics development programs.
• Experience working across multiple projects simultaneously in a fast-paced, cross-functional environment.
• Excellent written/oral communication, organizational, and interpersonal skills are required to work effectively across teams.

#LI-KB1 #LI-Hybrid

U.S. Pay Range

$147,200.00 - $220,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.