Assistant/Associate Project Scientist - Protein Dynamics - QB3 Berkeley

The QB3 Berkeley Department at the University of California, Berkeley seeks applications for an Assistant/Associate Project Scientist in the Marqusee Lab, in the area of Protein Dynamics.

The PI lab develops methods for probing a protein's energy landscape (protein folding, dynamics and energetics). Many of the experiments rely on using hydrogen-deuterium exchange monitored by mass-spectometry. Recently the lab has developed new methods for probing the conformational landscape of viral fusion proteins in the native membrane environment using eVLPs. Current research is focusing on the effects of natural and designed variants. The lab is fully equipped with its own HDS-MS set up and the successful candidate will have direct access to this equipment.

The position will lead and complete ongoing experiments investigating the role of sequence variants on the energy landscape of viral fusion proteins - establishing experimental procedures, sample generation, HDX-MS experiments and analysis. The position will be responsible for keeping detailed laboratory notes, maintaining laboratory equipment, including the mass spectrometer and for generating figures and preparing first drafts of manuscripts. The position will also act as a liaison with collaborators to establish experimental protocols, coordinate sample generation and oversee HDX-MS generation in the laboratory.

The position will represent the lab and present work at collaborator meeting sand participate in the lab group meeting and journal clubs.

Lab: https://vcresearch.berkeley.edu/faculty/susan-marqusee

• PhD (or equivalent international degree) or enrolled in a PhD degree program (or equivalent international degree)

• PhD (or equivalent international degree)

* PhD (or equivalent international degree) in Biochemistry, chemistry, biophysics or a related field

* Three or more years of postdoctoral research experience is preferred.

* Experience in standard protein Biochemistry and molecular biology tools and experiments

* Experience in tissue culture to generate eVLPs

* Experience in hydrogen exchange mass spectrometry.

* Basic knowledge of protein folding

• 3 required (contact information only)

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