Job title: Associate Research Scientist Contractor, RNAi Formulations
Location: 65 Hayden Avenue, Lexington, MA, 02421
Duration : 1 year
REPORTING EXPECTATIONS: Onsite; Monday to Friday, 8:00 AM to 5:00 PM
TOP SKILLS PER MGR:
- Lab experience in formulation of oligonucleotides or antibodies for subcutaneous injection
- Hands on analytical characterization of oligonucleotides or antibodies/protein
- Experience with developability assessments, including evaluation of parameters like maximum solubility, viscosity, osmolality, limited chemical and physical stability
Job Description:
- The Associate Research Scientist Contractor, RNAi Formulations, will be based within Non-Viral Delivery (NVD) in Research & Early Development. This is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleotide delivery activities for injectable therapeutics.
Relationships
- Reports to the US Team Manager for Nucleic Acid Delivery, Formulations and Bioanalysis. Interacts closely with peers and cross-functional partners specializing in non-viral delivery, formulation development, oligonucleotide chemistry, stability assays, PK, bioanalysis, CMC, and external collaborators.
Essential Functions
- Support the development and characterization of preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
- Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
- Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, , and stability assessments.
- Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
- Support long-term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations.
- Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
- Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
- Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
- Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.
Qualifications And Skills
- MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related discipline.
- Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred.
- Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, , stability, or other developability assessments for complex oligonucleotide or antibody/protein formulations.
- Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage.
- Strong experimental planning, documentation, data analysis, and problem-solving skills.
- Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions.
- Awareness of external trends and advances in RNA delivery, oligonucleotide therapeutics, and clinical translation is a plus.
- A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus.
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Spectraforce Technologies
Sep 10, 2026