Postdoctoral Research Associate (Gumpper Lab)

A global higher education leader in innovative teaching, research and public service, the University of North Carolina at Chapel Hill consistently ranks as one of the nation's top public universities and is among is the top ten research universities in the nation for federal research expenditures as well as for federally funded social and behavioral sciences research and development.

Here at Carolina, our highly skilled postdocs play a vital role in our research enterprise and towards our overall commitment to research excellence. Across many disciplines, postdocs contribute to the intellectual vitality of the University. They provide innovative ideas and perspectives, foster a stimulating research environment and advance knowledge within their fields. Postdocs are crucial members of our scientific research workforce, contributors to our research outputs and an important reason why Carolina is one of the leading public research institutions in the country.

UNC-Chapel Hill offers postdocs comprehensive medical and vision coverage, paid leave, and benefits and services that support professional development and a healthy work/life balance. Chapel Hill regularly ranks as one of the best college towns and best places to live in the United States, a reputation guided by the diverse social, cultural, recreation and professional opportunities that span the campus and community.

The UNC Eshelman School of Pharmacy (www.pharmacy.unc.edu) is one of six health science schools (Pharmacy, Nursing, Dentistry, Social Work, Public Health, Medicine) at the University of North Carolina at Chapel Hill and is one of the oldest health science academic programs at Chapel Hill. The School teaches approximately 600 PharmD students and 145 graduate students. The School has built a reputation for its continued pursuit of excellence, rigorous education and training programs, cutting-edge multidisciplinary research, progressive pharmacy practices, efficient business operations, and its outstanding faculty, staff, and students. The School was named the number one School of Pharmacy in the U.S. by the U.S. News and World Report. The School has experienced unprecedented growth and success and continues to strategically position itself for sustained impact, as articulated in the School's Strategic Plan (https://pharmacy.unc.edu/about/oe/strategic-plan/).

Our Vision is to be the global leader in pharmacy and pharmaceutical sciences. Our Mission is to prepare leaders and innovators to solve the world's most pressing health care challenges. We are Advancing Medicine for Life through innovation and collaboration in pharmacy practice, education, research, and public service.

G-protein-coupled receptors (GPCRs) play an important role across many important physiological systems (i.e. taste, vision, cardiac function, and neurotransmission). We are interested in the molecular mechanisms responsible for the nuanced signaling paradigms of GPCRs and how they lead to vastly different biological outcomes. Gaining atomistic insights into receptor-ligand interactions will allow us to design novel therapeutic compounds and molecular probes (rationally or through computational approaches).

As a model system, we study psychedelics. These compounds exhibit a complex polypharmacology impacting the serotonin, dopamine, and adrenergic receptor systems. While we are interested in investigating all receptor systems that psychedelics impact, we primarily study the 5-HT2A and 5-HT2C receptors. We want to develop novel therapeutic approaches exploiting these systems to create safer and more effective compounds for pain relief and neuropsychiatric disorders.

To interrogate these systems, we utilize state-of-the-art technologies and techniques in molecular pharmacology, structural biology, and computational biophysics.

Molecular Pharmacology and Chemical Biology:
We use various biochemical/pharmacological techniques to quantify the downstream signaling pathways and interaction partners related to GPCR activation. Additionally, we are interested in fully characterizing psychedelic polypharmacology (both structurally and mechanistically) and utilizing those pathways to develop novel compounds that can be used to treat chronic pain, neuropsychiatric disorders, as well as substance use disorders.

Structural Biology:
We use cryo-electron microscopy to reveal the molecular interactions between a drug and its receptor. This provides useful information for probing specific atomistic mechanisms that drive downstream signaling patterns and yield important interactions for structure-based drug design.

In Silico Approaches:
We use the latest computational approaches (MD simulations, docking, pipeline development) to reveal mechanistic insights into the dynamics of ligands and their receptors. Additionally, we use the latest developments in AI and ML and apply them with our expertise in structural biology and biochemical characterization.

PhD

Proficient in protein expression and cryo-EM. Molecular cloning and PCR. Working with mammalian cell culture is a plus.

The successful candidate will be a highly motivated, independent, and creative scientist with demonstrated experience in protein purification and structure determination by cryo-electron microscopy. The ideal applicant will have a strong track record of solving challenging structural biology problems, along with the ability to design, execute, and interpret experiments with minimal supervision. They will be intellectually curious, collaborative, and eager to contribute to an interdisciplinary research environment spanning molecular pharmacology, structural biology, and computational biophysics. A driven candidate will bring strong problem-solving skills, scientific rigor, and enthusiasm for using mechanistic insights to advance the discovery of novel therapeutic compounds and molecular probes.

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If you experience any problems accessing the system or have questions about the application process, please contact the University's Office of Postdoctoral Affairs at (919) 962-9982 or send an email to opahr@unc.edu.

Please note: The Office of Postdoctoral Affairs will not be able to provide specific updates regarding position or application status.

The University is an equal opportunity employer and welcomes all to apply without regard to age, color, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, or sexual orientation. We encourage all qualified applicants to apply, including protected veterans and individuals with disabilities.