Scientist II

Position Title: Scientist II

Work Location: South San Francisco, CA, 94080

Assignment Duration: 6 Months

Work Arrangement: Fully onsite

Position Summary:

Join our cutting-edge research team as a vital member of our Viral Vector Core. In this role, you will drive the production, analytics, and development of next-generation viral vectors. This is an exciting opportunity for a collaborative, detail-oriented researcher to support our gene therapy pipeline, contribute to innovative therapeutic modalities and facilitate our research community in applying viral vectors as powerful research tools.

Background & Context:

Support The Organization's gene therapy pipeline through viral vector services.

Key Responsibilities:

* Core Viral Production & Analytics: Deliver high-quality viral vector core services, including the end-to-end production of lentiviral libraries and Adeno-associated virus (AAV), as well as robust downstream viral vector analytics.

* Data & Inventory Management: Maintain a meticulously organized virus inventory and registry utilizing our digital informatics platforms to ensure data integrity and traceability.

* Next-Gen Modality Engineering: Assist with the engineering, production, and technology development of novel viral vectors and emerging viral-based modalities.

* Application of Viral Vector and CRISPR technologies: Actively participate in the advanced in vitro and in vivo genome engineering using CRISPR/Cas9 systems.

Qualification & Experience:

* Proficient in mammalian cell culture and general molecular biology techniques such as transient plasmid transfection, PCR, qPCR, ddPCR, dPCR and Western blot.

* Working experiences with lentivirus or AAV production and application, CRISPR technology for genome editing are highly desirable.

* Experience with flow cytometer operations, electronic notebook and proficiency in data analysis and computational programming are also strong plus.

* Must be self-motivated, detail-oriented, analytical, highly organized, and have excellent communication and interpersonal skills.

* MS or PhD degree in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related discipline with 3+ years of laboratory research experience.

* Years of experience: 5 to 10 years.