New

Pharmacology Senior Research Associate

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
May 27, 2026
Job Description General Summary: The Pharmacology Senior Research Associateconducts independent research to evaluate the effects of compounds on in vivo disease biology, with a strong emphasis on in vivo pharmacology and surgical execution in rodent models. This role requires excellent technical skills, strong attention to detail, and the ability to troubleshoot and adapt experimental approaches. The ideal candidate will have hands-on experience with rodent surgical procedures, including kidney-related surgeries such as renal pelvis injection, and a strong understanding of kidney anatomy. Large animal in vivo surgical experience is a plus.This individual should demonstrate strong in vivo technical expertise, scientific rigor, and the ability to generate high-quality data in a collaborative research environment. In addition to technical strength, the successful candidate will bring a strong team-oriented mindset, a positive, can-do attitude, and a willingness to support team and project goals. Key Duties and Responsibilities: Execute and interpret in vivo experimentswith a high level of reliability, independence, and scientific rigor Perform and support in vivo pharmacology studies, primarily in rodent models Conduct rodent surgical procedureswith strong technical proficiency, including kidney surgeries such as renal pelvis injection Apply knowledge of kidney anatomyto support study planning, surgical execution, tissue collection, and data interpretation Perform core in vivo procedures, including: Animal handling Dosing via multiple routes of administration (ROAs) Blood and other fluid sample collection Perfusion, necropsy, tissue dissection, and tissue processing Contribute to experimental planning and support prioritization of studies based on project impact Perform basic statistical analyses, as appropriate Routinely troubleshoot experiments and refine methods to improve study outcomes Prepare clear protocols, surgical procedures, and written study reports Maintain awareness of relevant scientific literature, technical advances, and disease area trends Present study results clearly and effectively at internal meetings Work collaboratively across teams and contribute positively to a highly interactive research environment Perform additional duties as assigned Knowledge and Skills: Strong hands-on experience in in vivo pharmacology, with demonstrated success in rodent studies Proven technical expertise in rodent surgical procedures, particularly kidney surgery, including renal pelvis injection Strong understanding of kidney anatomyand its application to experimental design, surgical procedures, and tissue evaluation Experience with a broad range of in vivo techniques, including animal handling, dosing via multiple ROAs, perfusion, fluid collection, and tissue dissection/processing Large animal in vivo and/or surgical experience is a plus Strong analytical and problem-solving abilities, including data interpretation and protocol refinement Consistent reliability in experimental execution, data quality, and study delivery Effective written and verbal communication skills Strong teamwork spirit, a collaborative mindset, and a can-do attitude Developing knowledge of related scientific disciplines Education and Experience: Bachelor's degree in a biological science required Typically requires: Bachelor's degree with 4+ years of experience, or Master's degree with 0-2 years of experience, orequivalent combination of education and experience Pay Range: $76,100 - $114,100 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com