New

Senior Scientist II (Preclinical Bioanalysis)

Exelixis
paid holidays, sick time, 401(k)
United States, California, Alameda
Apr 30, 2026
SUMMARY/JOB PURPOSE: The Senior Scientist II of preclinical bioanalysis provides preclinical bioanalytical support for the advancement of the biologics portfolio at Exelixis. The incumbent must have strong LCMS-based bioanalysis experience as s/he supports preclinical activities of ongoing and new projects in antibody drug conjugates and other biologics. ESSENTIAL DUTIES AND RESPONSIBILITIES: Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices, perform pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection. Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed. Critical scientific/technical data analysis and interpretation of experiments. Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement. Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams. Contribute to other translational biology efforts Follow company intellectual property and compliance policies and practices. Comply with company health and safety policies and general laboratory practices. SUPERVISORY RESPONSIBILITIES: Directing work to a CRO, Consultant, or 3rd party as necessary EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: Education: Master's degree in analytical chemistry or biology or closely related discipline and a minimum of seven (7) years of related experience; or PhD degree in analytical chemistry or biology or closely related discipline and a minimum of two (2) years of related experience is preferred; or Equivalent combination of education and experience. Experience: Hand-on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics is essential. Scientific understanding of in vitro* and in vivo pharmacology, PK, and PD concepts in cancer biology is important. Knowledge/Skills: Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems. Knowledge and familiarity in LC-MS-based bioanalysis is critical Ability to work independently, good time management and organization skills. Knowledge and experience of ligand-binding assays and metabolite ID is a plus Excellent written, oral, and interpersonal communication skills. A strong team player. Advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad prism. Good tracking record and report writing. WORKING CONDITIONS: Environment: primarily working in laboratories or in office Exposures encountered, such as hazardous materials, and extreme cold. Travel required (up to 10%) #LI-HG1 If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career with us!* Our compensation reflects the cost of labor across severalU.S. geographic markets, and we pay differently based on those defined markets. The base pay range for this positionis $132,500 - $188,000 annually. The base pay range may take into account the candidate's geographic region, which will adjust the pay depending on the specific work location. The base pay offered will take into account the candidate's geographic region, job-related knowledge, skills, experience and internal equity, among other factors. In addition to the base salary, as part of our Total Rewards program, Exelixis offers comprehensive employee benefits package, including a 401k plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. Employees are also eligible for a discretionary annual bonus program, or if field sales staff, a sales-based incentive plan. Exelixis also offers employees the opportunity to purchase company stock, and receive long-term incentives, 15 accrued vacation days in their first year, 17 paid holidays including a company-wide winter shutdown in December, and up to 10 sick days throughout the calendar year. DISCLAIMER The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job. We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.