Scientist

Position Title: Scientist

Work Location: Ridgefield, CT 06877

Assignment Duration: 24 Months

Work Schedule: Ability and willingness to support weekend work as needed.

Work Arrangement: Onsite (Inferred based on Vivarium/Laboratory requirements)

Position Summary: Independently initiates and completes routine in vivo studies efficiently, with minimal supervision.

Interprets experimental outcomes and recommends appropriate follow-up.

Background & Context: The Organization is seeking a technical expert to support the development and validation of rodent models for cardiometabolic diseases within a fast-paced research environment.

Key Responsibilities:

• Independently initiates and completes routine in vivo studies efficiently, with minimal supervision.
• Interprets experimental outcomes and recommends appropriate follow-up.
• Demonstrates technical proficiency supporting the development and validation of rodent models for cardiometabolic diseases.
• Applies basic scientific principles with minimal guidance; performs literature searches and extracts relevant information from published protocols.
• Proposes new ideas and technologies, builds support, and implements improvements based on scientific and technical expertise and an understanding of the drug discovery and development process.
• Independently operates and maintains laboratory equipment and troubleshoots issues effectively.
• Communicates work effectively, both orally and in writing; contributes to protocols, procedures, and technical reports; and provides input for scientific reports.
• Records, analyzes, and reports data with a high level of integrity and ethical conduct.
• Complies with applicable regulations and performs all work safely; maintains accurate records in accordance with Standard Operating Procedures and policies.

Qualification & Experience:

• Master's Degree with 2-3 years experience or Bachelor's Degree with 3+ years experience in related scientific discipline; pharmaceutical, biotechnology or CRO experience is highly desirable; non-PhD applicant required.
• Understanding of physiology, pharmacology, and disease mechanisms relevant to cardio?renal biology.
• Contributes to design and execution of in vivo studies relevant to cardio-renal metabolic diseases (kidney injury, cardiovascular and metabolic driven cardio-renal dysfunction.)
• Perform dosing procedures (oral gavage, IP/IV/SC injections), physiological monitoring, and sample collection (blood, urine, tissues).
• Conduct functional assessments, such as blood pressure measurements, echocardiography support, telemetry, metabolic cage studies, and renal function assays.
• Process and analyze biological samples, including histology, biomarker assays, qPCR, ELISA, and other molecular or biochemical readouts.
• Maintain high-quality documentation, including study protocols, animal records, raw data, and reports compliant with internal and regulatory standards.
• Collaborate cross functionally with pharmacology, pathology, bioanalytics, and therapeutic area biology teams to interpret data and refine study designs.
• Ensure compliance with IACUC protocols, ethical animal care standards, and institutional guidelines.
• Strong communication skills and ability to work collaboratively in a fast?paced research environment.

Working Conditions & Physical Demands (If Applicable):

• Requires moderate physical activity to perform work in the vivarium and laboratory, including (but not limited to) standing for extended durations (>2 hours), working under a biosafety hood/cabinet for extended durations (>2 hours), bending, lifting (up to 20 lbs), squatting, pushing/pulling, and reaching.
• Requires daily handling and restraint of small laboratory animals (rats, mice; >50 at a time), often within a specified timeframe.
• Requires use of personal protective equipment (PPE), including respiratory, eye, hand, and foot protection.