Research Scientist, In Vivo Pharmacology (Oncology)
Job Description With over 35 preclinical targets in our pipeline! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy.
The successful candidate will join a dynamic, multi-disciplinary team of scientists in the Oncology Pharmacology group, playing a key role in the development of in-vivo models of cancer and their use for evaluating new drug candidates. Qualified applicants will be proficient in animal handling techniques, possess practical knowledge of biological assays and have extensive experience in sterile techniques for tissue culture and immune cell expansion.
In addition, applicants will exhibit strong communication and organizational skills, critical problem-solving abilities, and a commitment to excellence. Prior experience with oncology xenograft models for use in efficacy and PK/PD studies is required. Knowledge of immunology and experience with immunological assays is a plus.
Key responsibilities and opportunities:
* Develop, validate, and implement relevant in-vivo oncology-related xenograft models including subcutaneous and orthotopic xenograft models, syngeneic tumor models and PBMC and/or T cell adoptive transfer models for profiling the pharmacological effects of drug candidates.
* Carry out ex-vivo pharmacodynamic studies tailored to the molecular target of interest, including cellular and molecular readouts, and flow cytometric analysis
* Engineer cell lines using standard molecular biology techniques
* Responsible for execution, analysis, documentation and reporting of experiments for the evaluation of pre-clinical oncology drug candidates
* Present results within a multidisciplinary team environment EEO Statement The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Minimum requirements What you'll bring to the role:
* BS/MS in Pharmacology, Molecular Biology, Biochemistry, Cell Biology or related field with 2+ years of industry or academic experience
* Hands-on in vivo experience to execute pre-clinical studies is required
* Experience with standard molecular and cell biology techniques, such as qPCR, Western blot, engineering cell line is a plus
* Knowledge of cancer biology, cell signaling and immunology is a plus
* Ability to independently design and conduct experiments.
* Strong analytical, communication and organizational skills and critical problem-solving abilities
* Commitment to excellence, collaboration and learning
769 million. That's how many lives our products touch. At Novartis, being there when and how it matters most for our patients and customers allows us to live our purpose and help bring maximum impact to health outcomes.
Furthering our commitment to transforming medicine for patients, Novartis is embarking on an ambitious and exciting journey to reinvent how we use technology, data and customer insights to better serve our consumer's needs and put them on a path to better health. This includes taking bold approaches that begin with a customer-centric mindset and harness the power of today's digital and data-driven healthcare revolution to continue to improve and extend even more people's lives.
* Do you want to help people understand their disease and how to seek out the proper treatment for it?
* Do you want to support patients achieve the best possible outcomes?
* Do you want to deliver a leading customer experience at all touchpoints?
* Do you want to be at the forefront of leveraging today's technology advances to create tomorrow's healthcare innovations?
We believe the answers are found when curious, adventurous, and collaborative people like you are brought together in an inspiring environment. Where you're given opportunities to utilize the power of digital and data to individualize and maximize interactions with customers. Where you're empowered to not fear failure when taking smart risks. And most importantly, where you're surrounded by people who share your determination to tackle the world's toughest medical challenges.
Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse team's representative of the patients and communities we serve.
Join our Novartis Network:
If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network Business Unit Oncology NIBR Work Location Cambridge, MA Company/Legal Entity NIBRI Functional Area Research & Development
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Novartis Group Companies
June 17, 2022