Scientific Leader, In Vivo Pharmacology

Job Title: Scientific Leader In Vivo Pharmacology - Oligonucleotide Discovery

Location: 200 Cambridge Park Drive, Cambridge, MA

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Find out more: Our approach to R&D

Position Overview: We are seeking a highly motivated Scientific Leader to join the In Vivo Pharmacology team at GSK. The individual will be involved in designing and executing PK/PD studies supporting the advancement of oligonucleotide therapeutics. The successful candidate will bring deep hands-on expertise in rodent and non-human primate (NHP) models, strong experimental design skills, and direct experience with molecular assays, including qPCR. The individual will be a highly organized professional who can manage multiple projects simultaneously while maintaining quality. This role demands equal parts of operational excellence and scientific expertise. The role will be a key contributor to preclinical development programs.

Key Responsibilities:

• Design, lead, and execute in vivo studies in rodent and nonhuman primate (NHP) models to support target validation, lead optimization, and candidate selection.

• Manage and oversee in vivo studies conducted internally or with external CRO, including scope definition, protocol review, operational activities, data quality oversight, and scientific interpretation and communication of results.

• Ensure timely scheduling, execution, and delivery of in vivo studies in alignment with project plans, milestones, and decision points; proactively identify risks and implement mitigation strategies.

• Apply deep subjectmatter expertise in the biology, pharmacology, and delivery for evaluating oligonucleotide therapeutics or related modalities in preclinical models.

• Analyze, interpret data and communicate results clearly and objectively to key internal stakeholders.

• Collaborate cross-functionally with DMPK, non-clinical safety, chemistry, in vitro and project teams to ensure robust study design and data generation.

• Experience with handson molecular biology assays, with a strong emphasis on qPCR, including assay development, optimization, execution, and data analysis from in vivo samples is strongly preferred.

Basic Qualifications:

• PhD in Pharmacology, Biology, Biochemistry, or a related scientific discipline, with minimum 4+ years of relevant industry experience.
• Three or more years of experience in in vivo PK/PD study design and execution in rodent and non-human primate models.
• Two or more years of experience working with oligonucleotide therapeutics in a preclinical setting is required.
• Three or more years of experience independently designing studies, troubleshoot complex experimental challenges, and delivering high-quality data.
• Three or more years of experience conducting in vivo techniques, including dosing, tissue collection, and related procedures, is required.

Preferred Qualifications:

• Experience working in a pharmaceutical or biotechnology research environment.
• Experience in working and managing CROs
• Hands-on experience with qPCR assays, including assay development, optimization, and data analysis of in vivo samples.
• Track record of delivering data for regulatory submissions or IND-enabling packages.
• Excellent written and verbal communication skills, with the ability to present data clearly to multidisciplinary teams.

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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