Intern Cell Line Development

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte hasestablisheda portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology,Oncologyand Inflammation & Autoimmunity.

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

This11-week summer internship is designed forseniorundergraduate, Master's, or PhD studentsseeking exposure to a professional, corporate environment. The internship is project-based, with each intern assigned one clearly defined project aligned to the hosting department's priorities.

The role emphasizes learning, skill development, and practical application of academic knowledge while contributing to meaningful work.

Project Scope:

The goal of this project is to compare two Neon electroporation systems in terms oftransfection efficiency,cell viabilitypost transfection, andbulk pool titer. The two systems will be evaluatedside by sideunder matched experimental conditions. The project will include the following experimental components:

1. GFP Transfection Efficiency Assessment

• Transfect CHO host cells with a GFP plasmid.

• Measure the percentage ofGFP positivecells using theGUAVA flow cytometer.

1. TPOR DNA Preparation

• Linearize theTPORplasmid DNA.

• Perform purification of the linearized DNA to ensure high-quality material for transfection.

1. TPOR DNA Transfection and Bulk Pool Development

• Transfect CHO host cells with the linearized TPOR DNA.

• Initiate bulk pool development with selection pressure.

• Monitorcell viabilityandVCDthroughout pool expansion.

1. Bulk Pool Titer and Product Quality Analysis

• Continue bulk pool development until material is ready to set up fed-batch.

• Measuretiterand evaluateproduct quality attributes.

Summary:

By comparingtransfection efficiency,post transfectionviability, andbulk pool titeracross the two electroporation systems, we willdeterminewhether the newNxTElectroporation Systemcan effectively replace the legacy system.

Key Responsibilities:

• Independently plan and execute project tasks with manager guidance

• Analyze data or information and draw actionable conclusions

• Collaborate with cross-functional stakeholders as appropriate

• Communicate progress and challenges proactively

• Deliver a final presentation with findings, outcomes, and recommendations

Learning & Development Opportunities:

• Exposure to real-world decision-making and project ownership
• Development of advanced analytical, technical, and communication skills
• Networking with professionals and leaders across the organization
• Insight into potential full-time career paths

Minimum Requirements:

• Senior undergraduate, Master's, or PhD student at time of internship
• Demonstrated ability to work independently and manage ambiguity
• Strong analytical, organizational, and communication skills
• High level of initiative and accountability

Conversion Opportunity:

• Interns whodemonstratestrong performance, skill alignment, and cultural fit may be considered for full-time employment following the program, based on business needs and role availability.

Please note program duration:June 1 - August 14, 2026.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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