Director, Chemistry Technology DevelopmentBrisbane, CA

CareDx, Inc. is a leading precision medicine solutions company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers. CareDx offers products, testing services, and digital healthcare solutions along the pre- and post-transplant patient journey, and is the leading provider of genomics-based information for transplant patients.

We are seeking a motivated and innovative Senior Scientist to join our dynamic R&D team. In this role, you will contribute to the development of cutting-edge diagnostic solutions, leveraging your expertise to drive assay development and validation projects. Collaboration is key, as you will interface with cross-functional teams, including bioinformatics, biostatistics, data science, clinical operations, and regulatory affairs. Proficiency in molecular biology methods for nucleic acid characterization and related applications is essential, along with a critical and creative approach to problem-solving.

Responsibilities:

• Grow and lead a team of chemists, train junior scientists for safe and effective laboratory techniques. Manage chemistry safety and proper handling of chemicals and solvents
  
• Evaluate and optimize processes and materials within the Chemistry R&D operations
  
• Initiate, design, and execute experiments to develop and/or improve high-value novel technology for development of diagnostic tests
  
• Use organic chemistry synthetic, analytical and informational tools to independently develop and optimize processes for chemistry technology innovations
  
• Provide expert support and guidance regarding experiment design, data analysis, and results to the broader scientific team. Participate in troubleshooting.
  
• Collaborate across multiple departments to ensure seamless integration of scientific insights into broader research goals
  
• Build oligonucleotide R&D operations starting with selection of instrumentations, organizing the lab area, handling of the materials and waste. Develop purification and analytical methods
  
• Listen to the technological demands and issues that can be addressed by chemistry innovative solutions. Lead implementation of new technologies into improvements in the current processes and into development of new CareDx products and services
  

Qualifications:

• Ph.D. in organic chemistry with 5+ years of relevant. Candidates with a BS or MS in organic chemistry and significant industrial experience (5-10 years) may also be considered. Technology development experience in Life Sciences is preferred
  
• Experience in synthesis, analysis and conjugations of oligonucleotides. Experience with building research oligo operations is preferred
  
• Solid foundation organic chemistry, with hands-on experience in synthetic organic chemistry. Familiarity with DNA sequencing chemistry is a plus
  
• Expertise in nucleic acid extraction, purification and target enrichment techniques
  
• Strong interdisciplinary communication skills to foster collaboration and effective knowledge exchange
  
• Fabrication of superparamagnetic beads and nanoparticles for use in novel diagnostics technologies. Good practical knowledge in surface modifications for bioaffinity and antifouling
  
• Experience in scale-up in organic synthesis, managing safety and cost issues from R&D to materials production. Writing SOPs and QC/QA related process documentation
  
• Excellent organizational skills with acute attention to detail, ensuring high-quality outputs in a fast-paced environment
  
• Familiarity with fluorescent dyes and labeling using conjugation methods
  
• Personal qualities of a team leader and innovator

Additional Details:

Every individual at CareDx has a direct impact on our collective mission to improve the lives of organ transplant patients worldwide. We believe in taking great care of our people, so they take even greater care of our patients.

Our competitive Total Rewards package for US Employees includes:

• Competitive base salary and incentive compensation
• Health and welfare benefits, including a gym reimbursement program
• 401(k) savings plan match
• Employee Stock Purchase Plan
• Pre-tax commuter benefits
• And more!
• Please refer to our page to view detailed benefits athttps://caredx.com/company/careers

In addition, we have a Living Donor Employee Recovery Policy that allows up to 30 days of paid leave annually to a full-time employee who makes the selfless act of donating an organ or bone marrow.

With products that are making a difference in the lives of transplant patients today and a promising pipeline for the future, it's an exciting time to be part of the CareDx team. Join us in partnering with transplant patients to transform our future together.

CareDx, Inc. is an Equal Opportunity Employer and participates in the E-Verify program.

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