New

Scientist, Preclinical Operations

Ardelyx
life insurance, parental leave, paid holidays, flex time, 401(k)
United States, California, Newark
Jan 28, 2026
Description Ardelyx is a publicly traded commercial biopharmaceutical company founded with a mission to discover, develop and commercialize innovative first-in-class medicines that meet significant unmet medical needs. Ardelyx has two commercial products approved in the United States, IBSRELA (tenapanor) and XPHOZAH (tenapanor). Ardelyx has agreements for the development and commercialization of tenapanor outside of the U.S. Kyowa Kirin commercializes PHOZEVEL (tenapanor) for hyperphosphatemia in Japan. A New Drug Application for tenapanor for hyperphosphatemia has been approved in China with Fosun Pharma. Knight Therapeutics commercializes IBSRELA in Canada. Position Summary: We are seeking a Scientist, Preclinical Operations to join our experienced drug discovery and development team and help advance our gastrointestinal (GI) and cardiorenal research programs. The successful candidate will contribute to the development of GI/cardiorenal translational and biomarker strategies and provide scientific support across multiple drug programs. A key component of this role will be coordinating and monitoring work conducted by contract research organizations (CROs), with a focus on evaluating drug targets and mechanisms involved in GI and cardiorenal pathophysiology in support of the company's discovery and development efforts. Responsibilities: Identify, establish and manage collaborations with CROs and academic institutions and key opinion leaders in relevant disease areas for research projects Assist with the development and execution, through CROs, relevant in vivo models critical for evaluating compound activity, mechanism of action, and generation of key data sets that drive drug programs Review, analyze, and summarize data; prepare high-quality presentations for internal discussions Support drug discovery efforts, including scientific due diligence and preclinical de-risking of GI/cardiorenal opportunities Collaborate with drug development teams to generate IND-enabling data Track project resources and invoices Author scientific reports and supporting documentation for IND submissions Qualifications: Ph.D. in biology, pharmacology, or related discipline with 2 - 5 years of related experience or equivalent experience Experience outsourcing work to CROs located in the US or abroad Prior experience in the pharmaceutical or biotechnology industry preferred Experience or knowledge in gut physiology, including the role of intestinal receptors and transporters, is desirable Strong commitment to high-quality research and timely, organized execution of research plans Excellent written and verbal communication skills, with the ability to collaborate effectively in a dynamic, cross-functional team environment The anticipated annualized base pay range for this full-time position is $131,000 - $160,000. Ardelyx utilizes industry data to ensure that our compensation is competitive and aligned with our industry peers. Actual base pay will be determined based on a variety of factors, including years of relevant experience, training, qualifications, and internal equity. The compensation package may also include an annual bonus target and equity awards, subject to eligibility and other requirements. Ardelyx also offers a robust benefits package to employees, including a 401(k) plan with generous employer match, 12 weeks of paid parental leave, up to 12 weeks of living organ and bone marrow leave, equity incentive plans, health plans (medical, prescription drug, dental, and vision),life insurance and disability, flexible time off, annual Winter Holiday shut down, and at least 11 paid holidays. Ardelyx is an equal opportunity employer.