Associate Research Scientist

The Tong Lab in the Department of Biological Sciences at Columbia University invites applications for an Associate Research Scientist. The incumbent should have a full set of experimental skills in structural biology, including protein expression and purification in bacteria and insect cells, protein crystallization, X-ray diffraction data collection and processing, crystal structure determination and refinement, cryo-EM grid preparation and screening, cryo-EM data analysis, cryo-EM model building and refinement, structural analyses and mutagenesis studies.

The responsibilities of this position will include:

* Cryo-EM studies of Integrator proteins and their complexes with other proteins.

* Crystallographic studies of proteins involved in RNA processing, alone and in complex with substrates/inhibitors.

* Detailed analyses of the structures that are obtained, and design mutagenesis experiments to assess the structural observations.

* Working closely with collaborators, within Columbia and with other institutions, on multi-faceted projects.

* Preparing reports for grant submissions and drafting manuscripts detailing the results of studies for publication.

* Mentoring PhD students and colleagues on related projects.

Application materials received by February 17, 2026 will recieve full consideration. Application screening will begin immediately and will continue until the position is filled.

Minimum Degree Required: PhD

Field(s) of Specialization: Biological Sciences, Molecular Biology and Biochemistry

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.