Research/Sr. Research Investigator, High-Throughput Experimentation (HTE) Process Chemist

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)

This role will leverage high-throughput experimentation to drive process optimization, support automated impurity synthesis in process and library synthesis in collaboration with discovery, scale-up manufacturing and generate structured datasets to train AI models for predicting yield, selectivity etc. in process development.

Essential Functions of the Job (Key responsibilities)

* Execute high-throughput experimentation (HTE) to identify optimal reaction conditions for process development, enabling efficient, scalable, and robust chemical processes.

* Operate and maintain HTE and automation equipment, ensuring daily functionality, troubleshooting issues, and coordinating timely repairs with vendors and service providers.

* Participate in data integration out of HTE experiments into AI-driven modeling pipelines, continuously refining predictive models for reaction yield, selectivity virtual screening.

* Participate in cross-functional collaboration with Process Chemistry, Discovery, QC, QA, and external partners.

* Provide scale-up support for drug candidates in both non-GMP early development and cGMP clinical production, including route design, reaction optimization, and cost-effective manufacturing strategies.

* Support technology transfer to Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) and review cGMP manufacturing documentation.

Qualifications (Minimal acceptable level of education, work experience, and competency)

* PhD in organic chemistry, or equivalent relevant industry experience.

* Expertise in high-throughput experimentation (HTE), automation and workflows to support AI-driven modeling and decision-making.

* Strong proficiency in synthetic organic chemistry, with deep understanding of reaction mechanisms and synthetic methodologies and a proven publication record.

* Demonstrated excellence in problem-solving skills, with sound, technically driven decision-making ability.

* Outstanding written and verbal communication skills and interpersonal skills.

* An innovative team player with high energy for dynamic company environment.

* On-site presence required.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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