Vice President, US Health Economics & Outcomes Research (HEOR)

Sirtex Medical is a global leader in healthcare, with offices in the U.S., Australia, Germany, and Singapore, dedicated toimproving patient outcomes.

Our mission is to be at the forefront of minimally invasive cancer and embolization therapies. By partnering withphysicians, we aim to provide innovative products that enhance patient outcomes and simplify treatments. Achievingthis ambitious goal requires passionate and talented individuals who are committed to making a difference. Our flagshipproduct, SIR-Spheres Y-90 resin microspheres, is a targeted radiation therapy for liver cancer. To date, we havedelivered over >150K doses across 50+ countries, significantly impacting patients' lives worldwide. Our success is fueledby our dedication to serving the medical community, maintaining professionalism, fostering a collaborative work culture,nurturing an entrepreneurial spirit, and continuously pursuing innovation and improvement.

At Sirtex, we are committed to creating a great workplace. We offer a range of benefits, programs, and services tosupport our employees, ensuring they have opportunities to contribute to our success and advance their careers. Joinour inclusive community, where you can collaborate with talented colleagues, bring your ideas to life, and advance yourcareer, all while delivering innovative healthcare solutions to patients.

Position Summary

The Vice President, US Health Economics & Outcomes Research (HEOR) will provide strategic and operational leadership for all US HEOR activities, with primary accountability for CMS focused reimbursement strategy, payer value evidence, and business development asset evaluations. The role will lead the development of US specific economic and real-world evidence to support Medicare coverage, coding, payment, and pricing decisions across the portfolio and pipeline.

The role has a predominant US focus, with selective strategic support for Canada and limited engagement in other international markets as needed. This position is particularly well suited to candidates with experience in medical devices, interventional oncology, radiopharmaceuticals, or other specialty technologies where provider economics and Medicare payment systems are critical.

In addition, the VP will act as a key HEOR partner to Business Development, supporting licensing, acquisition, and pipeline prioritization decisions through rigorous assessment of US commercial value, reimbursement risk, and evidence requirements.

NOTE: This position is required to be based in the Boston/Woburn, MA area and report to the office a minimum of 3 days/week, unless traveling for work. All candidates must live in or be willing to relocate to the Boston area.

Key Responsibilities:

US HEOR & CMS Strategy (Primary Focus)

• Own and lead the US HEOR strategy to optimise access, coverage, reimbursement, and pricing across the product lifecycle.
• Serve as a senior internal authority on CMS reimbursement pathways, including buy and bill economics, site of care dynamics, coding and payment mechanisms (e.g., APCs, DRGs, add-on payments), and policy evolution.
• Shape evidence strategies aligned to CMS and US commercial payer expectations, with particular attention to medical device and radiopharmaceutical reimbursement models.
• Oversee development of US focused economic models (budget impact, cost-effectiveness where relevant, provider economics) and real-world evidence (RWE) using claims, EMR, and registry data.
• Lead development and governance of US value materials, including AMCP dossiers, ICER submissions, payer value tools, and CMS-relevant evidence packages.
• Support innovative reimbursement and value-based arrangements through HEOR insights.

Business Development & Asset Valuation

• Act as a core HEOR leader supporting business development, licensing, and M&A activities, with a strong focus on US value assessment.
• Evaluate early and late-stage assets to inform US commercial attractiveness, pricing potential, reimbursement feasibility, coding/payment risk, and evidence gaps.
• Partner with BD, US Market Access, and Commercial to deliver payer and provider focused value assessments, scenario modelling, and investment recommendations.
• Provide HEOR input into diligence processes, deal structuring, and portfolio prioritisation decisions.

Canada & Select International Market Support

• Provide strategic HEOR input to support Canadian market access and reimbursement, ensuring alignment with global value positioning.
• Offer selective HEOR support to other priority international markets as required, leveraging US/ Canada insights to inform evidence generation and value messaging.
• Coordinate with global HEOR counterparts to ensure consistency while maintaining a US first approach.

Cross-Functional Leadership

• Partner closely with US Market Access, Reimbursement, Medical Affairs, Clinical Development, Regulatory, Commercial, and Business Development to deliver integrated access strategies.
• Serve as a senior HEOR representative in governance forums and portfolio reviews.
• Lead, mentor, and develop HEOR talent; manage external vendors, academic collaborators, and consultants to ensure high-quality delivery.

Communication & Dissemination

• Present HEOR insights to senior leadership, translating complex analyses into clear, decision-oriented recommendations.
• Represent the organisation at key scientific and payer forums (e.g., ISPOR, AMCP).
• Drive publication and dissemination strategy in peer-reviewed journals and scientific congresses.

• Advanced degree (PhD, PharmD, MPH, MS, or equivalent) in Health Economics, Public Health, Epidemiology, Pharmacy, Engineering, or a related discipline required.
• 10+ years of progressive HEOR experience in medical device, radiopharmaceutical, biotech, or healthcare consulting environments required.
• Demonstrated depth of experience with CMS reimbursement, Medicare policy, and US payer evidence expectations.
• Strong track record supporting medical device or specialty technology reimbursement, including provider economics and site of care considerations.
• Experience in radiopharmaceuticals or nuclear medicine preferred but not essential.
• Significant experience supporting business development assessments, asset valuation, and deal diligence.
• Hands on leadership of economic modeling and RWE programs.
• Experience across pre and post launch assets.
• Familiarity with Canadian reimbursement pathways and international HTA systems is a plus.

Core Competencies

• US focused strategic mindset with strong CMS and payer acumen
• Executive level communication and influence
• Strong people leadership and ability to operate in a matrixed environment
• High standards for scientific rigor and delivery excellence
• Entrepreneurial, resilient, and solution-focused

The target base salary range for this position will range from $283,000 to $355,000 annually.Individual compensation for this job requisition will be based on non-discriminatory factors, including your geographic location, skills, experience, education and other factors as they relate to the position requirements. Actual compensation may vary depending on the confirmed job-related skills and experience.

In addition to the expected base compensation, this role is eligible to participate in Sirtex's incentive programs (target bonus of 25% for this position)and benefit plans, which include paid sick and vacation time, health insurance and a generous 401k matching program.

All your information will be kept confidential according to EEO guidelines.

Do you want to be part of something bigger? A team whose impact stretches across the globe making a real difference to the quality of people's lives. Sirtex recognizes that well-being, financial health, and work-life balance are crucial for our employees to achieve personal success.

Sirtex offers qualified candidates:

• Diverse and flexible work arrangements to achieve the optimum balance between work and personal responsibilities.
• A culture of respect, diversity, collaboration, and innovation fostering inclusiveness and superior performance.
• Attractive compensation and benefit packages which are practical, robust and equitable.
• A commitment to support ongoing professional growth through career development, on the job experiences and training opportunities.
• Challenging work which supports the development of new and better ways to improve clinical outcomes for oncology treatment around the world.
• An unwavering commitment to company values, employee safety and excellence in everything we do.

Diversity drives innovation; inclusion fosters belonging, growth and success. Sirtex believes that it takes multiple perspectives and voices to create a culture and workplace which fosters engagement, teamwork, and employee satisfaction to perform our best and deliver on commitments. We are dedicated to fostering an environment where all employees feel valued, included, and can share their ideas so that we can exceed even our own expectations.

Sirtex is An Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status, age or any other characteristic protected under applicable law. Sirtex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.