Neurodegeneration Researcher - 137850

Under the general supervision of the Principal Investigator (PI), the Neurodegeneration Researcher is responsible for several laboratory management tasks, including mouse colony management, ordering and preparation of reagents. Perform independent research as a 'Neurodegeneration Researcher' for a Neurosciences laboratory focusing on experiments using rodent models of Alzheimer's Disease (AD). Research will involve live fluorescence imaging experiments in different neuronal preparations (acute slices, organotypic hippocampal slices and dissociated neurons). Assist in the preparation of cultured slices and neurons for their experiments and other lab members. Live fluorescence imaging requires the use of a two-photon fluorescence lifetime imaging microscope and specific data analysis methods. Involve with experimental design and troubleshooting.

Other experiments might involve molecular biology and biochemical analysis of proteins. Design and execute experiments to further understand the role of PSD-95 and other synaptic scaffolding proteins in the protection of dendritic spines affected by Alzheimer's disease in order to meet existing grant objectives/milestones and other funding objectives that support Alzheimer's disease research.

Manage and coordinate research efforts with other collaborators as appropriate for multidisciplinary research. Train technicians and students to ensure effective participation in laboratory projects, and perform other duties as needed.

• Theoretical knowledge in neurosciences, fluorescence imaging, or equivalent combination of education and experience.

• Knowledge and experience in technical competence in a wide variety of data processing and analysis techniques.

• Experience with live fluorescence imaging, confocal microscopy and image analysis methods.

• Demonstrated ability to independently contribute to experimental design, analysis and interpretation of results.

• Excellent time management and demonstrated organizational and multi-tasking skills. Ability to establish priorities, meet multiple and frequently changing deadlines with flexible schedule to complete experiments/projects.

• Working knowledge of standard research animal-use protocols.

• Excellent interpersonal skills including tact, diplomacy and flexibility with the ability to work well independently or in a team framework in conjunction with principles of community with staff, faculty, researchers, and other lab personnel.

• Strong computer skills using MS Word, Excel, PowerPoint, on Apple and PC, email system, and a variety of web-based programs. Demonstrated ability to create and maintain databases and learn new programs and applications with minimal direction.

• Knowledge of basic lab safety requirements/procedures; EH&S regulations and methods for handling, clean-up, and waste disposal for biohazardous materials.

• Knowledge of UCSD policies and procedures including all safety agencies.

• Knowledge and experience in technical writing and demonstrated ability to write and/ or assist with writing of manuscripts for publication. Ability to read, comprehend and discuss research materials.

• Employment is subject to a criminal background check and pre-employment physical.
• Must be willing to work with biohazardous materials.
• Must be willing to work with rodents.
• Must be willing to work flexible schedule in order to complete experiments as necessary.

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