Associate Scientist II/Scientist I (Biologics expression and purification)

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies. Our team of 350+ dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer.Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics' corporate culture promotes an atmosphere of innovation, open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

As a member of the Protein Science team, this individual will set up transfections to express proteins in mammalian cells followed by their purification and characterization to support the Biologics discovery pipeline.

Job duties

• Culture of mammalian cells in suspension following aseptic techniques and cell-line specific protocols.
• Transient transfection of cell lines or expansion of stable cell pools, from 3 ml - 10 L scale, to express proteins of interest. Monitor and optimize culture conditions to maximize protein quality and expression.
• Protein purification from milligram to gram scale using semi-automated FPLC systems.
• Analytical characterization of purified proteins to support research projects for drug discovery.
• Collect, analyze, and summarize experimental data in electronic lab notebook for archiving and sharing.
• Maintain lab and lab equipment in optimal functioning condition. Report any problems to supervisor.

Qualifications:

Education/Experience

Associate Scientist II

• Bachelor's degree in Biology or Biochemistry or a related field of study with a minimum of 2 years of bench-related experience

Scientist I

• Bachelor's degree in Biology or Biochemistry or a related field of study with a minimum of 3 years of bench-related experience

or

Master's degree in Biology or Biochemistry or a related field of study. Laboratory experience gained through undergraduate coursework, graduate research, or an internship is required. A minimum of 1 year of bench-related experience, strongly preferred.

Knowledge, Skills and Abilities

• Experience with mammalian cell culture, transfections, maintaining cell lines, etc. with meticulous sterile technique and lab practices.
• Experience with recombinant protein purification and analytical characterization (CE or SDS-PAGE, SEC).
• Experience with experimental design and execution with minimal supervision.
• Experience with standard lab software for data analysis (MS Excel, Prism, etc.). Good organizational skills and ability to multi-task.
• Good verbal and written communication skills. Demonstrated ability to work in a collaborative environment with other team members.
• Willingness to work on occasional weekends.

Preferred Experience

• Experience with antibody purification using automated FPLC system.
• Experience with quantitative assays (BLI Octet, ELISA, etc.).

Supervisory Responsibilities: None

Additional Information

The annual rate of pay for the Associate Scientist II position ranges from $67,200 - $102,500. The annual rate of pay for the Scientist I position ranges from $84,400 - $128,800. For non-exempt roles, and according to applicable regulations, there may be the possibility for overtime pay. This role is eligible for the Company's discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Company's benefits programs, including medical / dental / vision / prescription coverage, employee wellness resources, 401(k) plan with employer match, access to an Employee Stock Purchase Plan, (ESPP), paid time off & paid parental leave benefits, and disability benefits.

The annual pay rate range is described in good faith, and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidate's experience, qualifications, geographic location, and other factors permitted by law. The Company may ultimately pay more or less than the posted range, and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned, vested, and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.