Director Translational & Clinical Genetics

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. GSK has kicked off 2025 with impressive growth in sales, profits, and earnings. We anticipate five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. So far, we have secured two FDA approvals, with three more expected later this year. By uniting science, technology, and talent, we are committed to getting ahead of disease together.

We are seeking a highly experienced, motivated and innovative individual to join us as a Director in the Translational & Clinical Genetics team, which is part of the broader GSK Human Genetics and Genomics organisation. The successful candidate will provide strategic leadership and undertake hands-on analyses to identify, develop and deliver a portfolio of translational data-driven activities to impact the GSK portfolio. You will have strong expertise in genetics, with particular emphasis on causal inference approaches, and demonstrable experience of integrating genetics with genomics (especially proteomics) and clinical phenotypic data. Your work will have application across therapeutic areas and will inform target discovery, biomarker discovery, disease and mechanistic understanding, indication and patient subgroup selection, and parsing treatment response using precision medicine approaches.

The successful candidate will lead a team of direct reports and work in a multidisciplinary, collaborative and scientifically driven environment interacting with GSK scientists and leaders from a range of functions and external collaborators to advance drug discovery and clinical development. You will have the opportunity to identify, establish and oversee collaborations with external institutions aligned with strategic priorities. Additionally, you will be encouraged and supported in the ongoing development of your scientific leadership through your impactful work and its visibility to key stakeholders, completing development programmes, presenting your research and writing peer-reviewed publications.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Utilize deep expertise in statistical genetics and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to generate at-scale insights and address targeted translational scientific questions.

• Provide strategic leadership and hands-on analytical prowess to identify, develop, and deliver programs of work to impact the GSK drug development pipeline.

• Work within and lead cross-functional GSK project teams, with an emphasis on respiratory, hepatology, neurodegeneration, immunology and/or renal disease.

• Identify, set up and oversee external scientific collaborations.

• Effectively communicate analysis findings, with expert interpretation, to project teams both within and outside the GSK Human Genetics & Genomics organisation.

• Work with focus and agility to deliver personal and team deliverables against objectives, demonstrating strong statistical, analytic and critical thinking skills with understanding of the translational context of your work.

• Stay informed about emerging technologies and methodologies in translational genetics and, in particular, causal inference approaches, with evaluation of their potential and implementation in the organization as indicated.

• Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning within the team.

We are looking for professionals with these required skills to achieve our goals:

• PhD or equivalent advanced degree in a relevant scientific discipline (e.g. statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics or machine learning) with a history of impactful scientific publications and/or presentations.

• Extensive experience in genetics and conducting analyses that integrate genetics, genomics (particularly proteomics) and/or clinical phenotypic data to address translational questions in drug discovery and development.

• Expertise and leadership in genetic causal inference approaches (Mendelian randomization) with detailed understanding of emerging methodologies.

• Ability to drive the development and implementation of new methodologies and approaches to integrate genetics and genomics to answer translational questions in drug discovery and development.

• Demonstrated ability to understand key scientific questions and identify and develop innovative analytical solutions to answer them and impact the drug discovery pipeline.

• Strong proficiency in at least one of R and Python, with a track record of writing reproducible and scalable code that abides to FAIR principles.

• Experience of line management and supporting the professional development of team members.

• Demonstrated experience in effectively communicating complex scientific concepts to diverse audiences.

If you have the following characteristics, it would be a plus:

• Excellent collaboration and partnership skills to work effectively with internal stakeholders across functions.

• Experience of setting up and overseeing external collaborations

• Experience of working in different trusted research environments (TREs)

• Demonstrated ability to work effectively both independently and in multidisciplinary teams to meet project timelines.

• Familiarity with the stages of drug discovery and development

#LI-GSK*

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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