Principal Scientist/Sr Principal Scientist

As a lab-based Principal Scientist/Sr. Principal Scientist in the Complex Models group within the Respiratory, Immunology & Inflammation Biology Unit (RIIBU), you will contribute to the in vivo strategy and will lead the design and execution of preclinical in vivo experiments to support drug discovery projects from target validation through to clinical phases. You will have the opportunity to work on targets and in vivo models relevant to respiratory and immune-related diseases.

• Contribute to the design and lab/vivarium based execution of in vivo strategies for disease areas

• Contribute to the delivery of preclinical efficacy and mechanistic in vivo studies to enable PK/PD and translational biomarker data generation using robust study design principles in accordance with GSK principles, written standards and SOPs.

• Lead discussions to ascertain a robust understanding of scientific rationale, key objectives, endpoints and Go/No-Go decisions for in vivo models and studies, setting clear goals and timelines.

• Use deep understanding of PK/PD scientific principles to drive innovation and independently design, execute, analyze, and present in vivo studies as the In Vivo Leader (IVL) representative on portfolio projects with input from Biology Leader (BL), Project Leader (PL), and Complex Models Leadership Team.

• Understand and independently apply robust study design (RSD) principles, gain input from SMEs and matrix partners (e.g. LASG, Statistics, PK modelling, Histopathology, Dispensary, Biopharm and Chemistry) prior to seeking endorsement/recommendations for animal studies at Independent Scientific Review (ISR) forum and Pre-Study Briefings (PSB).

• Anticipate any potential challenges with experiments and independently resolve technical issues in experimental planning, setup and execution with minimal guidance.

• Lab/vivarium based execution to enable sample/tissue acquisition, processing, and analysis to enable integration of PK/PD and translational biomarker data from in vivo studies and where necessary utilize advanced ex vivo assay techniques such as Flow cytometry, ELISA's, MSD, Luminex and qPCR.

• Key contact for animal studies, including provision of out of hours procedures as required.

• Responsible for maintaining technical expertise/competency and confidence in rodent handling, dosing, blood and tissue collection, and measurements of biological/ physiological function (e.g. Organ function, Hemodynamics).

• Be familiar with Federal Laws surrounding animal use in research and the local governance process (IACUC, AUP).

• Be familiar with severity limits/constraints related to adverse effects and respond as required under IACUC, AUP and GSK Policy on Care, Welfare and Treatment of Animals.

• Take responsibility for assessing animal health and welfare, document findings, and act on them or seek expert advice when necessary.

• Work effectively with internal matrix partners (e.g. BL, PL, RTech).

• Lead animal studies placed externally (e.g. CRO, academic groups) including Study Monitoring responsibilities.

• Maintain accurate, up to date and detailed electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant written standards, SOPs, Risk Assessments and safety guidelines.

• Foster an enterprise culture of innovation, collaboration, inclusion, and continuous learning.

• Read scientific literature and apply it to in vivo strategy and studies.

• BSc in a biological science and 5+ years in vivo experience or PhD in a biological science and 2+ years in vivo experience either in industry or an academic environment.

• Hands-on experience managing lab/vivarium operations and conducting research using animal model systems, with a focus on Respiratory and/or Immunology studies.

• Practical and current experience of Flow cytometry (standard and spectral, including panel design), ELISA's, MSD, Luminex and qPCR is necessary.

• Possess clear written and verbal communication skills within the line and matrix teams including proficiency in Microsoft Office, Teams, and Sharepoint.

If you have the following characteristics, it would be a plus:

• Deep understanding of disease mechanisms and/or immune pathways and the ability to adapt/expand into novel disease areas and adopt new technologies.

• Deep working knowledge of robust study design (RSD) principles and experience of critiquing protocols.

• Extensive experience of rodent handling, dosing, tissue necropsy, and blood sampling including familiarity of IT systems to maintain accurate records, e.g.: Tick@Lab, eLN, PACT.

• Thorough understanding of animal welfare and 3Rs and use of this knowledge to balance study design to achieve scientific objectives.

• Demonstrate problem-solving skills (e.g. during planning and in-life phase of studies/experiments)

• Possess the ability to independently and critically analyze in vivo data using appropriate data visualization software and statistical methods (e.g. demonstrate proficiency with GraphPad Prism and Spotfire).

• Proven ability to work independently as well as collaboratively in a team-oriented environment.

• Practical experience of Flow cytometry, ELISA's, MSD, Luminex and qPCR is necessary.

• Excellent written and verbal communication skills within the line and matrix teams including proficiency in Microsoft Office, Teams, and Sharepoint.

• Be able to oversee (as Study Monitor) external animal studies conducted at CRO or academic groups.

• Possess the flexibility to manage multiple studies in distinct phases of experimental conduct.

• Awareness and application of risk assessments and SOPs and local safety practices to ensure a safe working environment.

• Keep up to date with the relevant literature and be able to write and critique scientific documents and be able to independently communicate scientific ideas and findings, both verbally and in written form to internal teams.

• Demonstrate learning agility.

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