Associate Director, Biotherapeutic Engineering & Bioconjugation

Job Description Summary

Job Description

• Leads a team of 4 labs and 15-20 subject matter experts on the San Diego site responsible to drive recombinant therapies to patients.
• Establishes mid- and long-term goals, plan of action and implementation for the BEC team (e.g. annual objectives) in line with BRC and BR strategy and objectives. Identify and address obstacles to success both within and across departments.
• Integrating expertise from multiple sites and units, develops strategy and provides scientific leadership at a technical level in our core deliverable areas (Antibody Oligo Conjugates, Antibody Drug Conjugates, multispecifics).
• Represents BEC as BEC Site Head for the San Diego including managing the budget of the BEC unit in collaboration with global counterparts in order to meet BRC targets.
• Sets strategy, implements and manages outsourcing for the local BEC team.
• Interface with downstream development colleagues to bring lead candidates towards full development.
• Collaborates and coordinates activities with other global BRC and BR units.
• Offer innovative approaches to scientific questions and troubleshooting efforts to develop recombinant protein and antibody-based therapeutics in such areas as immune cell engagers, regulated/activatable antibodies, multispecific antibodies, and ADCs and AOCs.
• Identifies Disease Area's unmet needs and collaborate for a novel therapeutic solution.
• Ensure compliance for contemporaneous and accurate documentation of scientific activities and for ethical, health/safety, and quality assurance metrics

• PhD with 10 years relevant experience as an expert in protein engineering.
• Demonstrated ability to recruit, retains and develops diverse, and agile associates with different expertise, seniority and tasks to ensure long term talent development and talent pipeline including succession planning.
• Background in leading and mentoring a research group consisting of associates of all levels and acting as a manager of mangers.
• Proficiency in antibody molecular biology, protein expression, purification, chemical modification, analytics, biophysical characterization, functional characterization and functional assay design and interpretation.
• Familiarity with all aspects of antibody discovery, optimization, production, and transition to development/manufacturing groups.
• Familiarity with preclinical and early clinical development of biotherapeutics, including awareness of biomarker development, clinical assays, manufacturing, safety profiling, and clinical trial design

• Prior experience with computational protein design/modelling and structure analysis as well as library-based approaches to attenuate functional and developability properties of protein therapeutics.
• Proven experience developing and innovating on mixed modality therapeutics. Expertise designing and optimizing Antibody-Oligo Conjugates is highly desired.
• A demonstrated track record of success as judged by publications and patents.
• Highly collaborative spirit inside and outside of department to advance programs to clinic; good communication skills, creativity, and multi-tasking in a fast-paced environment.
• Ability to master new subjects and assess diverse scientific content related to the broader field of biologics drug discovery and development in a broad range of disease areas.

Novartis Compensation and Benefit Summary

The salary for this position is expected to range between $152, 600 and $283,400 per year.

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

Skills Desired