Executive Director, Pharmacology

Mannkind Corporation

United States, Massachusetts, Bedford

Jun 05, 2025

Position:
Executive Director, Pharmacology

Location:

Bedford, MA

Job Id:
111242

# of Openings:
1

About MannKind

MannKind Corporation focuses on the development and commercialization of innovative inhaled therapeutic products and devices to address serious unmet medical needs for those living with endocrine and orphan lung diseases. We are committed to using our formulation capabilities and device engineering prowess to lessen the burden of diseases such as diabetes, nontuberculous mycobacterial (NTM) lung disease, pulmonary fibrosis, and pulmonary hypertension. Our signature technologies - dry-powder formulations and inhalation devices - offer rapid and convenient delivery of medicines to the deep lung where they can exert an effect locally or enter the systemic circulation, depending on the target indication. With a passionate team of Mannitarians collaborating nationwide, we are on a mission to give people control of their health and the freedom to live life. Please visit mannkindcorp.com to learn more.

At MannKind, our people are our greatest asset. We're a mission-driven, collaborative organization united by a shared passion for developing life-changing therapies for those living with diabetes, pulmonary conditions, and other orphan diseases. We are committed to building a diverse, inclusive workplace and fostering a culture where every voice matters and every contribution counts.

Position Summary: We are seeking an Executive Director of Pharmacology to join our R&D team. This role will support our endocrine and orphan lung disease portfolios and lead the design, management, and evaluation of pharmacology studies from nonclinical through clinical trials and potential post-marketing studies. The ideal candidate will have strong expertise in testing various therapeutic modalities, ideally with experience in inhalation and pulmonary therapeutics. Experience with biomarkers, dosing strategy, PK/PD modeling, and designing clinical studies is essential. We are looking for someone who thrives in a dynamic, cross-functional environment and can work both strategically and hands-on.

Key areas of focus include vendor management, cross-functional collaboration, and driving the in vivo and in vitro strategy across the pipeline. The role includes accountability for scientific leadership and execution in both preclinical and clinical development settings.

Key Responsibilities:

Represent the pharmacology/toxicology function on drug development project teams across diverse indications, primarily in pulmonary and endocrine therapeutics.
Identify and implement preclinical models that reflect patient pathology; develop assays to support in vitro and in vivo assessments of efficacy or relevant biomarker activity.
Lead and oversee in vivo preclinical safety, PK/PD, and potential efficacy studies.
Lead Pharmacology/PK/PD activities on multiple projects; collaborate with R&D senior management to align scientific approaches with business objectives.
Partner with clinical and regulatory teams to design and support clinical studies with sound pharmacological rationale.
Define preliminary dosage and dosing regimens based on in vitro and in vivo data; partner with CMC and device teams to ensure feasible delivery approaches.
Serve as a scientific liaison with CROs and other external partners to execute and oversee studies.
Develop and communicate clinical pharmacology strategy in internal and external forums, including regulatory meetings.
Proactively recognize and solve technical and scientific challenges with innovative solutions.
Contributes to IND strategy and documentation, including pharmacology content for regulatory filings.
Translate complex scientific findings into clear, actionable insights for cross-functional teams.
Present scientific data effectively to both internal leadership and external stakeholders, including at conferences or regulatory/advisory board meetings.
Maintain scientific and technical expertise through continuous engagement with literature and industry developments.
Foster a collaborative, team-oriented culture.

Qualifications:

Ph.D. in Pharmacology, Pharmacokinetics, Biology, or related scientific fields.
15+ years of industry experience in pharmacology or translational sciences, with a focus on endocrine, pulmonary, or orphan indications.
Demonstrated experience with Nintedanib or other antifibrotic agents is highly desirable.
Strong knowledge of PK/PD modeling, dose selection, and biomarker integration into clinical trials.
Prior experience with IND and NDA filings; comfort interacting with regulatory authorities on pharmacology topics.
Proven ability to lead cross-functional teams, mentor junior scientists, and effectively manage external partners.
Excellent written and verbal communication skills, with the ability to present complex data to both technical and non-technical stakeholders.
Experience working in fast-paced biotech settings and comfort balancing strategic planning with hands-on execution.

Pay Range: $216,000 - $324,000 per year

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